C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 251/54 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61M 1/36 (2006.01) A61P 37/00 (2006.01) C07K 1/22 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2578995
The present invention comprises new compounds described by the following general formula:(I) NH2 where R is a straight chain or cyclic alkyl group, X is oxygen or sufur or an imino group or is absent, R' is an amino or metoxy group, or fluorine or chlorine atom and n is 0, 1 or 2. These compounds are useful for binding to tail or Fc portion of immunoglobulins and so have utility in those applications which require the non-covalent binding interaction of a molecule with the Fc portion of immunoglobulins. Such applications include the detection and purification of immunoglobulins as well as the treatment of certain autoimmune diseases.
La présente invention comprend de nouveaux composés décrits par la formule générale suivante:(I) NH2 où R est une chaîne droite ou un groupe alkyle cyclique, X est de l~oxygène ou du soufre, ou un groupe imino, ou est absent, R' est un groupe amino ou méthoxy, ou un atome de fluor ou de chlore et n est 0, 1 ou 2. L~utilité de ces composés réside dans leur capacité à se lier à la queue ou la partie Fc des immunoglobulines. Ils s~avèrent également pour les applications qui nécessitent une interaction par liaison non covalente d'une molécule avec la partie Fc des immunoglobulines. Ce type d~applications inclut la détection et la purification des immunoglobulines ainsi que le traitement de certaines maladies auto-immunes.
Abbott Shaun D.
Bienvenu Jean-Francois
Cameron Alan D.
Duceppe Jean-Simon
Ezzitouni Abdallah
Fasken Martineau Dumoulin Llp
Prometic Biosciences Inc.
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