C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/54 (2006.01) A61K 49/04 (2006.01) C07C 233/63 (2006.01) C07C 233/81 (2006.01) C07C 255/20 (2006.01) C07C 311/24 (2006.01) C07C 317/46 (2006.01) C07D 295/185 (2006.01)
Patent
CA 2191983
Compounds having structure (I) wherein Q is (II); n is an integer from 0 to 20; R1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; R2, R3, R4 and R5 are independently H, alkyl, fluoroalkyl, halogen, hydroxy, acylamino, acetamidoalkyl, cyano, sulfonyl, carboxamido or sulfonamido; R6 is alkyl, cycloalkyl, aryl or aralkyl; and R7 is H or -COR6 are useful as contrast agents in medical diagnostic x-ray imaging compositions and methods.
L'invention concerne des composés de structure (I) où Q représente (II); n est un entier compris entre 0 et 20; R?1¿ représente H, alkyle, fluoroalkyle, cycloalkyle, aryle, aralkyle, alcoxyalkyle ou acétamidoalkyle; R?2¿, R?3¿, R?4¿ et R?5¿ représentent indépendamment l'un de l'autre H, alkyle, fluoroalkyle, halogène, hydroxy, acylamino, acétamidoalkyle, cyano, sulfonyle, carboxamido ou sulfonamido; R?6¿ représente alkyle, cycloalkyle, aryle ou aralkyle; et R?7¿ représente H ou -COR?6¿. Ces composés sont utilisés en tant qu'agents de contraste pour rayons X dans des compositions et des procédés d'imagerie par rayons X destinés au diagnostic médical.
Bacon Edward R.
Daum Sol J.
Estep Kimberly G.
Nanosystems L.l.c.
Smart & Biggar
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