C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/54 (2006.01) A61K 31/34 (2006.01) A61K 31/415 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01) C07D 307/56 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2242794
Compounds according to the formula: (see fig. I) wherein: R1 and R2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; R3 and R4 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; and X and Y are located in the para or meta positions and are each selected from the group consisting of H, loweralkyl, oxyalkyl, and (see fig. II) wherein: each R5 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, ox alkylaryl or two R5 groups together represent C2 to C10 alkyl, hydroxyalkyl, or alkylene; and R6 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylamino, lkylaminoalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, aryl, or alkylaryl; or a pharmaceutically acceptable salt thereof, are disclosed. The compounds are useful for treating Pneumocystis carinii in a subject in need of such treattment.
Boykin David W.
Francesconi Iris
Tidwell Richard R.
Wilson W. David
Georgia State University
Sim & Mcburney
The University Of North Carolina At Chapel Hill
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