2,4-bis(trifluoroethoxy)pyridine compound and medicine...

Details 2,4-bis(trifluoroethoxy)pyridine compound and medicine... 2,4-bis(trifluoroethoxy)pyridine compound and medicine...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/496 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07D 213/69 (2006.01) C07D 213/73 (2006.01) C07D 213/75 (2006.01) C07D 235/02 (2006.01)

Patent

CA 2529207

A 2,4-bis(trifluoroethoxy)pyridine compound represented by the general formula (1): (1) X1 represents fluorine or hydrogen) or a salt of the compound; and a medicine containing the compound or salt as an active ingredient. The compound or salt has metabolic resistance to human hepatic microsome, satisfactory oral absorbability, and excellent ACAT inhibitory activity.

La présente invention concerne un composé 2.4-bis(trifluoroéthoxy) pyridine représenté par la formule (1) ou un sel du composé, ainsi qu'un médicament contenant le composé ou son sel en tant qu'ingrédient actif. Dans la formule, X?1¿ représente fluor ou hydrogène. Ce composé ou son sel présente une résistance métabolique au microsome hépatique humain, une absorbabilité par voie orale satisfaisante et une excellente activité inhibitrice ACAT. formule (1)

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