2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as...

Details 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as... 2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as...

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2398887

Pyrimidine derivatives of formula (I) wherein Q1, Q2, G and R1 are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture, pharmaceutical compositions and their use as cyclin-dependent serine/threonine kinase (CDK) and focal adhesion kinase (FAK) inhibitors are also described.

L'invention concerne des dérivés pyrimidine représentés par la formule (I) dans laquelle Q1, Q2, G et R<1> sont tels que définis dans les spécifications; et des sels pharmaceutiquement acceptables et des esters de ceux-ci hydrolysables <i>in vivo</i>. L'invention concerne les procédés de préparation desdits dérivés, des compositions pharmaceutiques et leur utilisation comme sérine/thrénine kinase (CDK) dépendant de la cycline, et comme inhibiteurs de kinase d'adhésion focale (FAK).

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