C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/241.5, 260/2
C07D 403/10 (2006.01) C07C 323/22 (2006.01) C07C 333/08 (2006.01) C07D 207/327 (2006.01) C07D 239/48 (2006.01) C07D 295/145 (2006.01)
Patent
CA 1108611
Abstract New antibacterially active 2,4-diamino-5-benzyl- pyrimidines of the formula Image wherein R1 denotes hydrogen or C1-6-alkyl; R2 denotes hydrogen; R3 denotes mercapto, C1-6-alkylthio, carboxy-C1-6-alkylthio, C1-6-alkoxy- C1-6-alkyl- thio, dimethylcarbamoylthio, -S(O)R' or -SO2R' and R4 denotes C1-6-alkylthio, -S(O)R' or SO2R', or R1 denotes hydrogen; R2 and R4 denote C1-? alkylthio, -S(O)R' or -SO2R', and R3 denotes C1-6-alkoxy, mercapto, C1-6-alkylthio, carboxy- C1-6-alkylthio, dimethylcarbamoylthio, -S(O)R', -SO2R' or -NR"R''', or R1 denotes hydrogen; R2 denotes C1-6-alkoxy; R3 denotes mercapto, C1-6-alkylthio, carboxy- C1-6-alkylthio, C1-6-alkoxy-C1-6-alkylthio, dimethylcarbamoylthio, -S(O)R' or -SO2R', and R4 denotes C1-6-alkylthio, -S(O)R' or -SO2R', or - 2 - R1 denotes hydrogen; R2 denotes halogen; R3 denotes C1-6-alkylthio, -S(O)R' or -SO2R', and R4 denotes C1-6-alkylthio, -S(O)R' or -SO2R', or R1 denotes hydrogen; R2 denotes halogen or C1-6-alkoxy; R3 denotes mercapto, C1-6-alkylthio, carboxy- C1-6-alkylthio, carbalkoxy-C1-6-alkylthio, cyano- C1-6-alkylthio, C1-6-alkoxy-C1-6-alkylthio, C1-6-alkoxy-C1-6-alkoxy-C1-6-alkylthio, dimethyl- carbamoylthio, -S(O)R' or -SO2R', and R4 denotes halogen or C1-6-alkoxy; R' denotes C1-6-alkyl; R: and R''' independently of one another denote hydrogen or C1-6-alkyl or together denote C2-6-aikylene (possibly with 1-3 double bonds), and their physiologically compatible salts, a process for their preparation, as well as pharmaceutical preparations based on these compounds and the production of said phar- maceutical preparations.
315867
Kompis Ivan
Wick Alexander E.
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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