2,4-diamino-pyridopyrimidine derivatives and their use as...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2599212

Compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof one of X1, X2 and X3 is N, and the others are CH; RN1 and RN2 together with the nitrogen atom to which they are attached form a nitrogen-containing heterocyclic ring having from 4 to 8 ring atoms; RN3 and RN4 together with the nitrogen atom to which they are attached form a nitrogen- containing heterocyclic ring having from 4 to 8 ring atoms and their use in treating diseases ameliorated by the inhibition of mTOR.

L~invention concerne des composés de la formule I: [INSERT FORMULA HERE] et des isomères, des sels, des solvates, des formes protégées chimiquement, et des promédicaments correspondants pour lesquels X¿1?, X¿2? et X¿3? sont N, et les autres sont CH ; R¿N1? et R¿N2? conjointement avec l~atome d~azote auquel ils sont fixés, constituent un anneau hétérocyclique contenant de l~azote ayant de 4 à 8 atomes cycliques ; R¿N3? et R¿N4? conjointement avec que l~atome d~azote auquel ils sont fixés, constituent un anneau hétérocyclique contenant de l~azote ayant de 4 à 8 atomes cycliques et leur application dans le traitement de maladies régressant suite à l~inhibition de mTOR.

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