C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/5513 (2006.01) A61P 37/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 453/02 (2006.01) C07D 471/08 (2006.01)
Patent
CA 2735730
[Problem] Provided is a compound which is useful as an active ingredient for a pharmaceutical having a PKC.theta. inhibition activity, particularly a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. [Means for Solution] The present inventors have conducted extensive studies on a compound having a PKC.theta. inhibition activity, and as a result, they have found that a compound having a structure such as aralkyl and the like on an amino group at the 2-position and also having a structure such as an adamantylalkyl group and the like on an amino group at the 4-position of 2,4-diaminopyrimidine, or a salt thereof has an excellent PKC.theta. inhibition activity, thereby completing the present invention. The 2,4-diaminopyrimidine compound of the present invention can be used as a PKC.theta. inhibitor or an inhibitor of acute rejection occurring in transplantation.
Cette invention concerne un composé utilisé comme agent médicinal ayant une activité inhibitrice de lenzyme PKC?, en particulier comme principe actif dune composition pharmaceutique servant à empêcher la crise de rejet lors des greffes. Des études ont été menées sur les composés à activité inhibitrice de lenzyme PKC?, qui ont confirmé quun composé caractérisé par une structure telle quun groupe aralkyle sur un groupe amino en position 2 et par une structure telle quun alkyle dadamantyle sur un groupe amino en position 4 dune 2,4-diaminopyrimidine ou un sel du composé, présente une excellente activité inhibitrice de lenzyme PKC?. Le composé 2,4-diaminopyrimidine peut être utilisé pour inhiber la PKC? ou empêcher la crise de rejet lors des greffes.
No affiliations
Astellas Pharma Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
2,4-diaminopyrimidine compound does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2,4-diaminopyrimidine compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,4-diaminopyrimidine compound will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1566334