2,4-diaminopyrimidine compounds useful as immunosuppressants

Details 2,4-diaminopyrimidine compounds useful as immunosuppressants 2,4-diaminopyrimidine compounds useful as immunosuppressants

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61K 31/5383 (2006.01) A61K 31/541 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) C07D 401/04 (2006.01) C07D 405/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2392971

Novel compounds according to formula (I) and pharma-ceutically acceptable salts, solvates, or hydrates thereof; wherein each occurrence of A is independently selected from CH or N; X is selected from the group consisting of -CH2-, -O-, -NH-, (C1-C6)alkylamino-, (C1-C6)alkylaminocarbonylamino-, (C1-C6)alkylcarbonylamino-, (C1-C6)alkylsulfonylamino-, phenylsulfonylamino-, carbonyl, -NH-C(O)-, -N(C1-C6)alkyl-C(O)-, -S(O)y- where y is 0, 1 or 2, and n in-(CH2)n- is 1, 2 or 3; and R1, R2, and R3 are as described herein; pharmaceutical compositions that include these compounds, and methods for the treatment of autoimmune disease, inflammation, allergy, transplant rejection, and other circumstances where administration of an immunosuppressive agent is of therapeutic benefit.

L'invention concerne de nouveaux composés de la formule I et des sels acceptables pharmaceutiquement, des solvates, ou des hydrates correspondants. Dans ladite formule, chaque occurrence de A est sélectionnée indépendamment parmi CH ou N, X est sélectionné parmi le groupe comprenant -CH2-, -O-, -NH-, (C1-C6)alkylamino-, (C1-C6)alkylaminocarbonylamino-, (C1-C6)alkylcarbonylamino-, (C1-C6)alkylsulfonylamino-, phénylsulfonylamino-, carbonyle, -NH-C(O)-, -N(C1-C6)alkyl-C(O)-, -S(O)y- où y est 0,1 ou 2, et n dans -(CH2)n- est 1, 2 ou 3, et R<1>, R<2> et R<3> sont comme décrits dans la présente invention. Ladite invention concerne également des compositions pharmaceutiques qui renferment ces composés et des méthodes de traitement de maladie auto-immune, d'inflammation, d'allergie, de rejet de greffe et d'autres circonstances lors desquelles l'administration d'un agent immunodépresseur présente un avantage thérapeutique.

Affiliated with

Also associated with

Rating

2,4-diaminopyrimidine compounds useful as immunosuppressants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2,4-diaminopyrimidine compounds useful as immunosuppressants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,4-diaminopyrimidine compounds useful as immunosuppressants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1411184