2,4-diaminopyrimidine derivatives

Details 2,4-diaminopyrimidine derivatives 2,4-diaminopyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/10 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) C07D 217/06 (2006.01) C07D 217/22 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2254117

The present invention is concerned with compounds of general formula (I), wherein R1 signifies lower-alkoxy, R2 signifies bromine, lower-alkoxy or hydroxy, R3 signifies hydrogen, lower-alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl or cyano, R4 and R5 each independently signify hydrogen, lower-alkyl, lower-alkoxy, halogen, hydroxy, amino, di(lower alkyl)- amino, cyano or nitro and Q signifies ethynylene or vinylene, pharmaceutically usable salts thereof, the use of these compounds and their salts as therapeutically active substances; medicaments based on these substances and their production; the use of these substances as medicaments and for the production of antibacterially-active medicaments; as well as the manufacture of the compounds of formula (I) and their pharmaceutically acceptable salts and intermediates for their manufacture.

L'invention concerne des composés de formule générale (I) et des sels de ceux-ci, utilisables en pharmacie. Dans ladite formule, R?1¿ signifie alcoxy inférieur, R?2¿ signifie brome, alcoxy inférieur ou hydroxy, R?3¿ signifie hydrogène, alkyle inférieur, cycloalkyle, aryle, hétéroaryle, aralkyle, hétéroaralkyle ou cyano, R?4¿ et R?5¿ signifient séparément hydrogène, alkyle inférieur, alcoxy inférieur, halogène, hydroxy, amino, di(alkyl inférieur)amino, cyano ou nitro et Q signifie éthynylène ou vinylène. L'invention concerne également l'utilisation de ces composés et de leurs sels comme substances thérapeutiquement efficaces; des médicaments à base desdites substances et leur production; l'utilisation de ces substances en tant que médicaments et pour la production de médicaments actifs en tant que bactéricides; ainsi que la fabrication des composés de formule (I) et leurs sels acceptables sur le plan pharmaceutique et leur intermédiaires pour leur fabrication.

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