C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61P 3/10 (2006.01) A61P 37/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2514612
Disclosed are novel compounds of formula (I) wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders and processes for preparing these compounds.
L'invention concerne de nouveaux composés de formule générale (I), dans laquelle R?1¿, R?2¿ et R?3¿ ont la signification indiquée dans la description, qui sont utiles en tant qu'inhibiteurs de l'enzyme PKC-theta et qui sont ainsi utiles dans le traitement de maladies et de troubles dont la médiation ou le prolongement est assuré par l'activité de l'enzyme PKC-theta, notamment les troubles immunologiques et le diabète de type II. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, des méthodes d'utilisation de ces derniers dans le traitement de maladies et de troubles divers, ainsi que des procédés de préparation desdits composés.?¿
Cardozo Mario G.
Cogan Derek
Cywin Charles Lawrence
Dahmann Georg
Disalvo Darren
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Boehringer Ingelheim Pharmaceuticals Inc.
Fetherstonhaugh & Co.
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