A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61P 25/06 (2006.01) C07D 239/42 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2438231
There is provided a method of treatment for disorders responsive to the modulation of KCNQ potassium channels by administering to a mammal in need thereof a therapeutically effective amount of a 2,4-disubstituted pyrimidine-5- carboxamide derivative of Formula (I) wherein R1, R2, R3, R4 and R5 are as defined in the description. The present invention also provides pharmaceutical compositions comprising openers or activators of the KCNQ potassium channels and especially to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine.
Cette invention concerne une méthode de traitement des troubles sensibles à la modulation des canaux KCNQ potassium. Ce traitement consiste dans l'administration, à un mammifère qui en a besoin, d'une dose efficace au plan thérapeutique d'un dérivé de 2,4-disubstitué pyrimidine-5-carboxamide représenté par la formule (I). Dans cette formule, R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ sont tels que définis dans le descriptif. La présente invention concerne également des compositions pharmaceutiques renfermant des ouvreurs ou des activateurs des canaux KCNQ potassium et tout particulièrement le traitement de troubles sensibles à l'activité de canaux KCNQ potassium, tels que la migraine.
Dextraze Pierre
Dodd Dharmpal S.
Dworetzky Steven I.
Gribkoff Valentin K.
Hewawasam Piyasena
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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