C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61P 3/04 (2006.01) A61P 25/20 (2006.01)
Patent
CA 2739919
The present invention is directed to 2,4-disubstituted pyrrolidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
La présente invention concerne des pyrrolidineamides 2,4-disubstitués qui sont des antagonistes des récepteurs de l'orexine, et qui peuvent être employés dans le traitement prophylactique ou thérapeutique de pathologies et de troubles neurologiques et psychiatriques faisant intervenir les récepteurs de l'orexine. La présente invention concerne également des compositions pharmaceutiques comprenant lesdits composés, ainsi que l'emploi desdits composés et compositions dans le traitement prophylactique ou thérapeutique de pathologies faisant intervenir les récepteurs de l'orexine.
Coleman Paul J.
Cox Christopher D.
Schreier John D.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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