C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 309/46 (2006.01) A61K 31/185 (2006.01)
Patent
CA 2179521
2,4-Disulpho-alpha-phenyl-tert-butyl nitrone of formula (I) and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral. e.g. intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss. The materials are also used to ameliorate the side effects of treatment of diseases which cause oxidative damage.
L'invention se rapporte à 2,4-disulfonyl .alpha.-phényl-<u>tert</u>-butyl-nitrone ainsi qu'à ses sels pharmaceutiquement acceptables. Ces substances sont utiles comme agents pharmaceutiques destinés à une administration orale ou parentérale, notamment une administration intraveineuse à des patients souffrant d'une oxydation aiguë du système nerveux central consécutive à une attaque, ou d'une oxydation graduelle du système nerveux central qui peut se manifester par une perte progressive des fonctions du système nerveux central. Ces substances s'utilisent également pour diminuer les effets secondaires de traitements antinéoplasiques entraînant des lésions oxydatives.
Fetherstonhaugh & Co.
Oklahoma Medical Research Foundation
The University Of Kentucky Research Foundation
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