2,4-pyrimidinediamine compounds and their uses

Details 2,4-pyrimidinediamine compounds and their uses 2,4-pyrimidinediamine compounds and their uses

C - Chemistry, Metallurgy

07

D

C07D 239/28 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) C07D 239/48 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2474277

The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compunds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

L'invention concerne des composés 2,4-pyrimidinediamine, inhibiteurs de cascades de signalisation de récepteur d'IgE et/ou d'IgG menant à la libération de médiateurs chimiques, des intermédiaires et des procédés de synthèse de ces composés, ainsi que des procédés d'utilisation des composés dans une variété de contextes, comprenant le traitement et la prévention de maladies caractérisées par, causées par ou associées à la libération de médiateurs chimiques <i>via</i> une dégranulation et d'autres processus mis en oeuvre par l'activation de cascades de signalisation de récepteur d'IgE et/ou d'IgG.

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