C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/506 (2006.01) A61K 35/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2533320
Novel pyrimidine derivatives of formula (I) Wherein R is selected from C16-10 aryl, C5-10heteroaryl, C3-12cycloalkyl and C3-10heterocycloalkyl; R0-R6 as described herein; and their use for the manufacture of a medicament for the treatment or prevention of a disease wich responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR.
La présente invention concerne de nouveaux dérivés de pyrimidine de formule (I) dans laquelle R est choisi entre aryle en C¿16-10?, hétéroaryle en¿ ?C¿5-10?, cycloalkyle en C¿3-12? et hétérocycloalkyle en C¿3-10?, et R?0¿-R?6¿ sont tels que définis dans l'invention. L'invention a également pour objet l'utilisation de ces dérivés pour produire un médicament destiné au traitement ou à la prévention d'une maladie qui répond à l'inhibition de FAK et/ou ALK et/ou ZAP-70 et/ou IGF-IR.
Chopiuk Greg
Ding Qiang
Garcia-Echeverria Carlos
Gray Nathanael Schiander
Jiang Jiqing
Fetherstonhaugh & Co.
Irm Llc
Novartis Ag
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