2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives

C - Chemistry – Metallurgy – 07 – C

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C07C 237/04 (2006.01) A61K 31/16 (2006.01) C07C 237/06 (2006.01) C07C 323/32 (2006.01) C07C 323/36 (2006.01)

Patent

CA 2226894

Novel 2-(4-substituted)-benzylamino-2-methyl-propanamides compounds, having CNS activity, of general formula (I) wherein: n is zero, 1, 2 or 3; X is -O-, -S-, -CH2- or -NH-; each of R and R1 independently is hydrogen, C1-C6 alkyl, halogen, hydroxy, C1-C4 alkoxy or trifluoromethyl; each of R2, R3 and R4 independently is hydrogen, C1-C6 alkyl or C3-C7 cycloalkyl; and the pharmaceutically acceptable salts thereof, are disclosed.

L'invention concerne les dérivés de 2-(4-substitué)-benzylamino-2-méthylpropanamides qui agissent sur le système nerveux central, représentés par la formule générale (I), où n vaut zéro, 1, 2 ou 3; X est -O-, -S-, -CH2- ou -NH-; R et R1 représentent chacun indépendamment hydrogène, alkyle C1-C6, halogène, hydroxy, alcoxy C1-C4 ou trifluorométhyle; R2, R3 et R4 représentent chacun indépendamment hydrogène, alkyle C1-C6 ou cycloalkyle C3-C7. L'invention concerne également les sels pharmaceutiquement acceptables de ces dérivés.

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