C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2745041
The present invention relates to pyridopyrimidine derivatives according to formula (I), as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
La présente invention concerne des dérivés de pyridopyrimidines de formule (I) en tant qu'inhibiteurs d'autotaxine, et l'emploi de tels composés dans le traitement prophylactique et/ou thérapeutique d'états physiologiques et/ou pathophysiologiques provoqués, médiés et/ou propagés par des niveaux supérieurs à la normale d'acide lysophosphatique et/ou l'activation de l'autotaxine, en particulier de différents cancers.
Kober Ingo
Krier Mireille
Schiemann Kai
Schultz Melanie
Staehle Wolfgang
Fetherstonhaugh & Co.
Merck Patent Gbmh
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