2,5-diaryl tetrahydrofurans and analogs thereof as...

Details 2,5-diaryl tetrahydrofurans and analogs thereof as... 2,5-diaryl tetrahydrofurans and analogs thereof as...

A - Human Necessities

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A61K 31/33 (2006.01) C07C 45/00 (2006.01) C07C 45/72 (2006.01) C07D 307/04 (2006.01) C07D 307/12 (2006.01) C07D 307/14 (2006.01) C07D 307/18 (2006.01) C07D 307/20 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01)

Patent

CA 1267417

TITLE OF THE DISCLOSURE NEW 2,5-DIARYL TETRAHYDROFURANS AND ANALOGS THEREOF AS PAF-ANTAGONISTS ABSTRACT OF THE INVENTION Analogs of 2,5-Diaryl tetrahydrofurans which were substituted or unsubstituted at 3,4-positions were prepared. These compounds are found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by the PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets.

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