2,5-diaryl tetrahydrofurans and analogs thereof as paf...

C - Chemistry – Metallurgy – 07 – D

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167/211, 260/266

C07D 405/04 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2018476

8642S 17937 TITLE OF THE DISCLOSURE NEW 2,5-DIARYL TETRAHYDROFURANS AND ANALOGS THEREOF AS PAF ANTAGONISTS ABSTRACT OF THE DISCLOSURE The present invention is directed to a æpecifically substituted tetrahydrofuran of the formula (I) Image wherein Ar is a pyridyl, dimethoxy-pyridyl or a dimethoxy-pyrazinyl group, R4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group, Y is an alkyl or substituted alkyl group, R6 is an alkyl or a substituted alkyl and the substituents at positions 3,4 and 5 are acyclic.

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