2,5-diaryl tetrahydrofurans and analogs thereof as paf...

Details 2,5-diaryl tetrahydrofurans and analogs thereof as paf... 2,5-diaryl tetrahydrofurans and analogs thereof as paf...

C - Chemistry, Metallurgy

07

D

167/211, 260/245

C07D 405/14 (2006.01) A61K 31/395 (2006.01) C07D 405/04 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2018474

8641S 17936 TITLE OF THE DISCLOSURE NEW 2,5-DIARYL TETRAHYDROFURANS AND ANALOGS THEREOF AS PAF ANTAGONISTS ABSTRACT OF THE DISCLOSURE The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) Image wherein Ar is a pyridyl, a dimethoxy-pyridyl or dimethoxy-pyrazyl group, R4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group and at least one of the substituents at positions 3,4 or 5 contains a heterocyclic, heteroaryl or substituted phenylthio group. TOTAL P.02

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