2,5-diaryl tetrahydrothiophenes and analogs thereof as...

Details 2,5-diaryl tetrahydrothiophenes and analogs thereof as... 2,5-diaryl tetrahydrothiophenes and analogs thereof as...

C - Chemistry, Metallurgy

07

D

260/328.2, 260/2

C07D 333/04 (2006.01) A61K 31/33 (2006.01) C07C 45/72 (2006.01) C07C 45/78 (2006.01) C07D 333/16 (2006.01) C07D 409/00 (2006.01)

Patent

CA 1266271

1220M/0627A 17043 TITLE OF THE DISCLOSURE NEW 2,5-DIARYL TETRAHYDROTHIOPHENES AND ANALOGS THEREOF AS PAF-ANTAGONISTS ABSTRACT OF THE INVENTION Analogs of 2,5-Diaryl tetrahydrothiophenes which were substituted or unsubstituted on 3,4-positions were prepared. These compounds are found to be leukotriene inhibitors and potent and specific PAF (Platelet Activating Factor) antagonists. They are therefore useful in the treatment of various diseases or disorders mediated by the leukotriene and/or PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets.

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