2,5-disubstituted arylsulfonamide ccr3 antagonists

Details 2,5-disubstituted arylsulfonamide ccr3 antagonists 2,5-disubstituted arylsulfonamide ccr3 antagonists

C - Chemistry, Metallurgy

07

D

C07D 211/96 (2006.01) A01N 43/62 (2006.01) A61K 31/18 (2006.01) A61P 11/02 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) C07D 241/04 (2006.01) C07D 241/08 (2006.01) C07D 295/26 (2006.01)

Patent

CA 2758968

Provided herein are 2,5-disubstituted arylsulfonamide CCR3 antagonists of Formula (I),(Ia) or (II), and pharmaceutical compositions thereof: wherein X, Y, Z, and R1 - R5 are as defined herein. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3 - mediated disorder, disease, or condition.

Linvention concerne des antagonistes CCR3 d'arylsulfonamides 2,5-disubstitués de formule (I), (Ia) ou (II) et des compositions pharmaceutiques de ceux-ci. Dans lesdites formules, X, Y, Z et R1-R5 sont tels que définis dans la description. L'invention concerne en outre des méthodes d'utilisation desdits antagonistes pour la prévention, le traitement ou l'amélioration d'un ou de plusieurs symptômes de troubles, maladies ou affections médiés par CCR3.

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