C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/10 (2006.01) A61K 31/415 (2006.01) A61K 31/4418 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/495 (2006.01) C07D 231/12 (2006.01) C07D 231/56 (2006.01) C07D 241/12 (2006.01) C07D 401/12 (2006.01) C07D 413/10 (2006.01)
Patent
CA 2741648
The present invention is directed to 2,5-disubstituted phenyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
La présente invention concerne des composés carboxamide phényl 2,5-disubstitué, qui sont des antagonistes du récepteur de lorexine et qui se révèlent utiles dans le traitement ou la prévention de troubles et maladies neurologiques et psychiatriques, ainsi que de maladies impliquant les récepteurs de lorexine. Linvention porte également sur des compositions pharmaceutiques contenant lesdits composés, ainsi que sur lutilisation desdits composés et compositions dans la prévention ou le traitement de telles maladies impliquant les récepteurs de lorexine.
Bergman Jeffrey M.
Coleman Paul J.
Roecker Anthony J.
Schreier John D.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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