C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/454 (2006.01) A61K 31/4709 (2006.01) A61K 31/506 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2739916
The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
La présente invention concerne des composés damide de pipéridine 2,5-disubstitués qui sont des antagonistes de récepteurs dorexine, et qui sont utiles dans le traitement ou la prévention de troubles et maladies neurologiques et psychiatriques dans lesquels des récepteurs dorexine sont impliqués. Linvention concerne en outre des compositions pharmaceutiques comprenant ces composés et lutilisation de ces composés et compositions dans la prévention ou le traitement de telles maladies dans lesquelles des récepteurs dorexine sont impliqués.
Breslin Michael J.
Coleman Paul J.
Cox Christopher D.
Raheem Izzat T.
Roecker Anthony J.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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