2,5-disubstituted pyridine, pyrimidine, pyridazine and 1, 2,...

Details 2,5-disubstituted pyridine, pyrimidine, pyridazine and 1, 2,... 2,5-disubstituted pyridine, pyrimidine, pyridazine and 1, 2,...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/44 (2006.01) A61P 29/00 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2446879

The present invention relates to inhibitors of P38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders. The inhibitors are of formula (I), (II) or (III) wherein the variables are as defined in the claims.

L'invention concerne des inhibiteurs de P38, une protéine kinase de mammifère impliquée dans la prolifération cellulaire, la mort cellulaire et la réponse aux stimuli extracellulaires. L'invention concerne également des méthodes de production desdits inhibiteurs. L'invention concerne en outre des compositions pharmaceutiques comprenant les inhibiteurs de l'invention et des méthodes d'utilisation de ces compositions dans le traitement et la prévention de divers troubles. Les inhibiteurs sont représentés par la formule (I), (II) ou (III) dans lesquelles les variables sont telles que définies dans les revendications.

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