2,5-inter-o-phenylene-3,4-dinor-pgf and pgi compounds

Details 2,5-inter-o-phenylene-3,4-dinor-pgf and pgi compounds 2,5-inter-o-phenylene-3,4-dinor-pgf and pgi compounds

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 307/935 (2006.01) C07C 405/00 (2006.01) C07D 307/937 (2006.01) C07D 311/94 (2006.01) C07D 405/10 (2006.01) C07F 9/54 (2006.01)

Patent

CA 1175822

3529-1 ABSTRACT Composition and Process This invention relates to certain structural and pharmacological analgos of prostacyclin (PGI2) and 5,6-dihydroprostacylcin (PGI1) and 5,9.alpha.-epoxy-9-deoxy- PGF1, wherein between the position beta to the carboxy (C-2) and C-5 there is substituted an inter-o-phenylene for the ethylene chain. These novel 2,5-inter-o- phenylene-3,4-dinor prostaglandin or prostacyclin type compounds are useful for certain of the same pharmacologi- cal purposes as prostacyclin, particularly being smooth muscle stimulators, blood pressure depressors and platelet aggregation inhibitors. Also provided are novel inter- mediates therefor, namely corresponding interphenylene- containing PGF2.alpha. and 5-halo-PGI1 and 6-halo-5,9.alpha.- epoxy-9-deoxy-PGF1 compounds.

339557

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