2,5-methanobenzo¬g| quinoline-3-carboxylate esters

Details 2,5-methanobenzo¬g| quinoline-3-carboxylate esters 2,5-methanobenzo¬g| quinoline-3-carboxylate esters

C - Chemistry, Metallurgy

07

D

260/237.85

C07D 221/26 (2006.01) C07D 211/82 (2006.01) C07D 221/08 (2006.01) C07D 221/22 (2006.01) C07D 453/06 (2006.01) C07D 471/08 (2006.01)

Patent

CA 1095905

ABSTRACT OF THE DISCLOSURE Lower-alkyl 1-R1-3-R5CO-4a.alpha.-R3-5.alpha.-R4-6-R2"-7-R2-8- R2'-9-R2'''-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]- quinoline-3-carboxylates, useful as intermadiates for the pre- paration of 3-R1-6(eq)-R4-7-R2"-8-R2-9-R2'-10-R2'''-11(ax)-R3- 11(eq)-CH2CH2COR5-2,6-methano-3-benzazocines, useful as anal- gesics and narcotic antagonists, are prepared by acylation of an appropriate lower-alkyl 1-R1-4a.alpha.-R3-5.alpha.-R4-6-R2"-7-R2-8-R2'- 9-R2'''-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quino- line-3-carboxylate or carboxylation of an appropriate 1-R1-3- COR5"-4a.alpha.-R3-5.alpha.-R4-6-R2"-7-R2-8-R2'-9-R2'''-1,2,3,4,4a,5,10,- 10a-octahydro-2,5-methanobenzo[g]quinoline.

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