C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/16 (2006.01) C12N 9/22 (2006.01) C12N 9/99 (2006.01) C12Q 1/44 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2498771
It is intended to provide a novel polypeptide having a 2~,5~-oligoadenylate phosphodiesterase activity; an antibody against this polypeptide; a polynucleotide encoding the polypeptide; a recombinant plasmid DNA having this polynucleotide inserted thereinto; host cells transformed by this recombinant plasmid DNA; a method of screening a 2~,5~-oligoadenylate phosphodiesterase activity inhibitor; a method of screening a 2~,5~-oligoadenylate phosphodiesterase expression controller/inhibitor; etc. The above-described polypeptide, polynucleotide, host cells and so on are useful as means of searching for remedies for viral infection, tumor, etc.
L'invention concerne un nouveau polypeptide présentant une activité de 2',5'-oligoadénylate phosphodiestérase ; un anticorps contre ce polypeptide ; un polynucléotide codant ce polypeptide ; un ADN plasmidique de recombinaison renfermant ce polynucléotide ; des cellules hôtes transformées par cet ADN plasmidique de recombinaison ; un procédé de criblage d'un inhibiteur de l'activité de 2',5'-oligoadénylate phosphodiestérase ; un procédé de criblage d'un régulateur/inhibiteur de l'expression de 2',5'-oligoadénylate phosphodiestérase ; etc. Ces polypeptide, polynucléotide, cellules hôtes et ainsi de suite sont utiles comme moyens de recherche de remèdes contre notamment des infections virales et des tumeurs.
Hara Ayako
Iijima Yasuteru
Kubota Kazuishi
Nakahara Kaori
Ozeki Yohei
Marks & Clerk
Sankyo Company Limited
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