2,5 or 2,6 disubstituted benzoxazoles

Details 2,5 or 2,6 disubstituted benzoxazoles 2,5 or 2,6 disubstituted benzoxazoles

C - Chemistry, Metallurgy

07

D

260/311.1

C07D 263/56 (2006.01) C07D 263/58 (2006.01)

Patent

CA 1038393

ABSTRACT OF THE DISCLOSURE A compound of formula II: Image (II) where the group Image is in the 5- or 6-position of the benzo- xazole nucleus, A is -CH2-, -CO-, Image , Image -NH or NCH3-; R4 is a phenyl group, R2 is hydrogen or methyl, and R3 is the group -COOR5, where R5 is C1-4 alkyl, or the group -COOH or an alkali or alkaline earth metal, aluminium or ammonium salt thereof. The phenyl group may be substituted by one or two groups selected from the group consisting of halogen, trifluo- romethyl, methyl, methoxy, acetyl and methylsulphonyl. The specification also discloses a process for preparing the above compound. The above compound has valuable pharmacological activities such as analgestic, antipyretic and/or anti- inflammatory activities.

212029

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