2,5-substituted aryl pyrroles, compositions containing such...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/04 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2228050

The present invention addresses 2,5-substituted aryl pyrroles of formula (I); or pharmaceutically acceptable salts thereof, as well as compositions containing such compounds and methods of treatment. The compounds are useful for treating Cytokine mediated diseases, which refers to diseases or conditions in which excessive or unregulated production or activity of one or more cytokines occurs. Interleukin-1(IL-1), Interleukin-6 (IL-6), Interleukin- 8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved in immunoregulation and other physiological conditions, such as inflammation. The compounds also have glucagon antagonist activity.

L'invention se rapporte à des pyrroles d'aryle substitués en position 2 et 5 correspondant à la formule (I) ou à un de leurs sels pharmaceutiquement acceptables, ainsi qu'à des compositions contenant de tels composés et à leurs modes d'utilisation. Les composés sont utiles dans le traitement des maladies induites par les cytokines, qui sont des maladies ou des pathologies dans lesquelles la production ou l'activité d'une ou de plusieurs cytokines est excessive ou non régulée. L'interleukine-1 (IL-1), l'interleukine-6 (IL-6), l'interleukine-8 (IL-8) et le facteur de nécrose tumorale (TNF) figurent parmi les cytokines qui interviennent dans l'immunomodulation et dans d'autres processus physiologiques, tels que l'inflammation. Lesdits composés ont également une activité antagoniste vis-à-vis du glucagon.

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