2,5-substituted benzolsulfonylureas and thioureas, methods...

Details 2,5-substituted benzolsulfonylureas and thioureas, methods... 2,5-substituted benzolsulfonylureas and thioureas, methods...

C - Chemistry, Metallurgy

07

C

C07C 335/42 (2006.01) A61K 31/64 (2006.01) C07C 311/58 (2006.01) C07D 213/40 (2006.01) C07D 307/52 (2006.01) C07D 333/20 (2006.01)

Patent

CA 2337397

The present invention relates to novel 2.5-substituted benzol sulfonyl ureas and thio ureas of formula (I). wherein R(1), R(2), R(3), R(4). X and Y have the meanings cited in the claims. The inventive compounds are useful active ingredients for medicaments The compounds of formula (I) act as inhibitors on ATP-sensitive potassium canals and are suitable for the treatment of cardio-vascular disorders, especially the treatment of arrhythmias, prevention of sudden death from heart disease or affect diminished contractility of the heart. The invention also relates to methods for producing compounds of formula (I), the use thereof and pharmaceutical preparations containing said compounds.

L'invention concerne des benzolsulfonyl-urées et -thiourées substituées en 2,5, leur procédé de production, leur utilisation et les préparations pharmaceutiques les contenant. La présente invention concerne de nouvelles benzolsulfonylurées et benzolsulfonylthiourées de la formule (I) où R(1), R(2), R(3), R(4), X et Y ayant la signification donnée dans la description sont des principes actifs efficaces de médicaments. Les composés de la formule (I) ont une action inhibitrice sur les canaux de potassium sensibles à l'ATP et conviennent, par exemple, au traitement d'arythmies, à la prévention de la mort soudaine par infarctus ou à l'action sur une contractibilité réduite du coeur. L'invention concerne également un procédé de production des composés de la formule (I), leur utilisation et les préparations pharmaceutiques les contenant.

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