2, 5-substituted pyrimidine derivatives as ccr-3 receptor...

Details 2, 5-substituted pyrimidine derivatives as ccr-3 receptor... 2, 5-substituted pyrimidine derivatives as ccr-3 receptor...

C - Chemistry, Metallurgy

07

D

C07D 409/14 (2006.01) A61K 31/506 (2006.01) A61P 11/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2490148

This invention relates to pyrimidine derivatives of Formula (I), wherein Ar1, Ar2, R1-R5, X, Z and alk are as defined in the specification. The compounds are useful as CCR-3 receptor antagonists and therefore, may be used for the treatment of CCR-3 mediated diseases.

L'invention concerne des dérivés de pyrimidine représentés par la formule (I); dans cette formule Ar?1¿, Ar?2¿, R?1¿-R?5¿, X, Z et alk sont tels que définis dans la spécification. Les composés décrits dans cette invention sont utiles en tant qu'antagonistes du récepteur CCR-3 et, de ce fait, ils peuvent être utilisés pour le traitement de maladies véhiculées par le CCR-3.

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