2(5h)-furanones substituted in the 3 position, as ca2+...

Details 2(5h)-furanones substituted in the 3 position, as ca2+... 2(5h)-furanones substituted in the 3 position, as ca2+...

C - Chemistry, Metallurgy

07

D

C07D 307/58 (2006.01) A61K 31/365 (2006.01) A61K 31/665 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2078770

2078770 9116048 PCTABS00007 Compounds of formula (1), in which R is alkyl, arylalkyl or substituted arylalkyl, or alkenyl containing one or more olephinic bond; X is O, NH or NR1, where R1 is alkyl of 1 to 20 carbons or arylalkyl; and Y is H, alkyl of 1 to 20 carbons, arylalkyl, aryl, substituted aryl, substituted arylalkyl, alkenyl containing one or more olephinic bonds, PO(OH)2, PO(OH)OR2, PO(OH)R2, PO(OR2)2, where R2 is independently alkyl of 1 to 20 carbons, phenyl, or substituted phenyl, further Y is CO-R3, CO-OR3, CONHR3, SO2R3, SO2NHR3, (CH2)n-O-R3, or (CH2)n-O-(CH2)m-O-R3, where n, and m, are integers and are independently 1 to 20 and R3 is H, alkyl, alkenyl containing one or more olephinic bonds, aryl, substituted aryl, arylalkyl or substituted arylalkyl, with the proviso that when Y is CO-R3, CO-OR3, and CONHR3 then R3 is not hydrogen, are disclosed. The compounds are Ca2+ channel antagonist, have weak or no activity as inhibitors of phospholipase A2, and are anti-inflammatory agents.

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