2(5h)-furanones substituted in the 5 and or in the 4...

C - Chemistry – Metallurgy – 07 – D

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C07D 307/58 (2006.01) A61K 31/365 (2006.01) C07D 307/28 (2006.01) C07D 307/30 (2006.01) C07D 307/60 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2078771

2078771 9116055 PCTABS00007 Compounds of formula (1), and compounds of formula (2) in which R1 is H, alkyl of 1 to 20 carbons, alkylene having one or more double bonds, alkyne having one or more triple bonds, arylalkyl, arylalkylene having one or more double bonds or arylalkyne having one or more triple bonds; R2 is H, alkyl of 1 to 20 carbons, alkylene having one or more double bonds, alkyne having one or more triple bonds, arylalkyl, arylalkylene having one or more double bonds or arylalkyne having one or more triple bonds; R3 is H, alkyl of 1 to 20 carbons, arylalkyl, or halogene, and X is H or alkyl of 1 to 20 carbons, CO-X*, CO-O-X*,, CO-NH-X*,, or PO(OX*,)2 or PO(OX*,)X*,, where X*, independently is H, alkyl of 1 to 20 carbons, phenyl, or substituted phenyl, are disclosed. However, in the compounds of the invention illustrated by formula (2), R1 and R3 both cannot be hydrogen. The compounds have anti-inflammatory activity.

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