2,6-bis-(aminoacylamino)-benzo-[1,2-d:5,4-d']- bisthiazoles...

Details 2,6-bis-(aminoacylamino)-benzo-[1,2-d:5,4-d']- bisthiazoles... 2,6-bis-(aminoacylamino)-benzo-[1,2-d:5,4-d']- bisthiazoles...

C - Chemistry, Metallurgy

07

D

260/278.1, 260/2

C07D 513/02 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1097635

ABSTRACT OF THE DISCLOSURE This invention relates to novel derivatives of 2,6- bisamino-benzo[1,2-d:5,4-d']-bisthiazole of formula Image [wherein R1 each is hydrogen or alkyl, R2 is hydrogen but at least one of R2 is Image (wherein R5 is hydrogen, alkyl, alkylaminoalkyl, carboxyalkyl, alkoxyalkyl, phenyl, morpholino, or optionally substituted cycloalkyl; R6 is hydrogen, alkyl, alkylaminoalkyl or alkoxyalkyl; or R5 and R6 together with the nitrogen atom form a 5-, 6- or 7- membered heterocyclic ring; and A is alkylene); and R3 and R4 each is hydrogen, chlorine, bromine, alkyl, alkoxy, acyl, carboxy, alkoxycarbonyl, carbamoyl, phenyl, trifluoromethyl, nitro, cyano or amino] and acid addition salts thereof. The novel compounds exhibit antiarthritic and antir- heumatic properties. Processes for the preparation of the novel compounds and pharmaceutical compositions containing them are described and claimed.

309176

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