C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/506 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2723205
The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation,and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.
L'invention concerne des composés de formule (I-II) et des tautomères, des sels, ou des stéréo-isomères de ceux-ci, qui sont acceptables du point de vue pharmaceutique, et qui constituent des inhibiteurs de Syk kinases et/ou de Janus kinases. L'invention concerne également des intermédiaires utilisés dans la fabrication de tels composés, la préparation d'un tel composé, des compositions pharmaceutiques contenant un tel composé, des procédés d'inhibition de l'activité de Syc kinases et/ou de Janus kinases, des procédés d'inhibition d'agrégation plaquettaire, et des procédés pour prévenir ou pour traiter un certain nombre de troubles au moins partiellement médiés par l'activité de Syc kinases et/ou de Janus kinases, comme une thrombose non voulue ou un lymphome non hodgkinien.
Bauer Shawn M.
Huang Wolin
Jia Zhaozhong J.
Mehrotra Mukund
Pandey Anjali
Fetherstonhaugh & Co.
Portola Pharmaceuticals Inc.
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