2,6-diaryl pyridazinones with immunosuppressant activity

Details 2,6-diaryl pyridazinones with immunosuppressant activity 2,6-diaryl pyridazinones with immunosuppressant activity

C - Chemistry, Metallurgy

07

D

C07D 237/24 (2006.01) A61K 31/445 (2006.01) A61K 31/50 (2006.01) A61K 31/52 (2006.01) A61K 31/535 (2006.01) A61K 31/66 (2006.01) A61K 38/13 (2006.01) C07D 405/04 (2006.01) A61K 31/71 (1995.01)

Patent

CA 2213135

A class of 2,6-diarylpyridazinones of general structural formula (I) have been identified that exhibit immunosuppressant activity with human T-lymphocytes, and are useful as an immunosuppressant or a pharmaceutically acceptable salt, hydrate or crystal form thereof.

L'invention concerne une classe de 2,6-diarylpyridazinones ayant la structure représentée par la formule (I), ainsi que leurs sels acceptables sur le plan pharmaceutique, leurs hydrates et formes cristallines. Il a été démontré que ces composés ont une activité immunosuppressive au niveau des lymphocytes T humains et qu'ils sont utiles en tant qu'immunosuppresseurs.

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