( )-2,6-dimethyl-4-(3-nitrophenil)-1,4-...

Details ( )-2,6-dimethyl-4-(3-nitrophenil)-1,4-... ( )-2,6-dimethyl-4-(3-nitrophenil)-1,4-...

C - Chemistry, Metallurgy

07

D

260/278

C07D 401/12 (2006.01) C07D 211/42 (2006.01) C07D 211/90 (2006.01)

Patent

CA 1246078

- 38 - ABSTRACT Disclosed are (?)-2,6-dimethyl-4-(3-nitrophenyl)- 1,4-dihydropyridine-3,5-dicarboxylic acid-3-(1-benzyl-3- piperidyl) ester-5-methyl ester, the melting point of the hydrochloride of which is 196 to 202°C [referred to as (?)- .alpha.-form], from among the diastereomers of 2,6-dimethyl-4-(3- nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-(1- benzyl-3-piperidyl) ester-5-methyl ester represented by the formula: Image and an optical isomer having an optical rotation degree of (+) from among (?)-.alpha.-form or a salt thereof, and these compounds depress blood pressure and dilate coronary artery and peripheral blood vessels and are useful as drug for cardiovascular diseases.

438995

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