A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/454 (2006.01) A61K 31/445 (2006.01) A61K 31/4545 (2006.01) A61K 31/46 (2006.01) A61P 29/00 (2006.01) C07D 211/22 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 451/02 (2006.01)
Patent
CA 2553242
The present invention is further directed to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R16, R17, R18, R19, R20, R21 and R22 are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
L'invention porte sur des composés de formule (I) (dans laquelle: R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿7?, R¿8?, R¿9?, R¿10?, R¿16?, R¿17?, R¿18?, R¿19?, R¿20?, R¿21? et R¿22?) sont définis dans la description, modulateurs de l'activité du récepteur de la chémokine et s'avérant utiles pour prévenir et traiter certains troubles et maladies à caractère inflammatoire et immunorégulatoire, des allergies, des états atopiques dont la rhinite allergique, les dermatites, la conjonctivite, et l'asthme, ainsi que des pathologies auto-immunes telles que l'arthrite rhumatoïde et l'athérosclérose. L'invention porte également sur des préparations pharmaceutiques comprenant ces composés, et sur l'utilisation de ces composés et préparations pour la prévention et le traitement de telles maladies où interviennent les récepteurs de la chémokine.
Goble Stephen D.
Mills Sander G.
Pasternak Alexander
Yang Lihu
Zhou Changyou
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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