2,6-methano-3-benzazocines

Details 2,6-methano-3-benzazocines 2,6-methano-3-benzazocines

C - Chemistry, Metallurgy

07

D

260/237.85

C07D 221/26 (2006.01)

Patent

CA 1097630

ABSTRACT OF THE DISCLOSURE 3,6(eq),11(ax)-Trimethyl-8-hydroxy-11(eq)-(CH2CH2COR)- 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines, where R represents certain selected lower-alkyl, phenyl-lower-alkyl or cycloalkyl-lower-alkyl groups, and acid addition salts thereof, are highly potent narcotic antagonists. Such compounds and related compounds containing 7,8,9 or 10-hydroxy-substitution can be prepared by cleaving the corresponding ethers having a lower-alkoxy substituent in that position.

298735

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