C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/14 (2006.01) A61K 31/47 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) C07C 43/205 (2006.01) C07C 205/49 (2006.01) C07C 229/40 (2006.01) C07C 233/87 (2006.01) C07C 237/36 (2006.01) C07C 309/65 (2006.01) C07D 215/22 (2006.01) C07D 215/36 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2484954
The present invention concerns 2,6-quinolinyl and 2,6-naphthyl derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for the treatment of VLA-4 dependent inflammatory diseases such as for example asthma, allergic rhinitis, sinusitis, conjunctivitis, food allergy, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and atherosclerosis. Formula (I): wherein X is N or CH.
L'invention concerne des dérivés de 2,6-quinolinyle et de 2,6-naphtyle de formule (I), dans laquelle X désigne N ou CH, leurs procédés de préparation, des compositions pharmaceutiques les renfermant et leur utilisation comme produits pharmaceutiques pour le traitement de maladies inflammatoires dépendantes de VLA-4, telles que, par exemple, asthme, rhinite allergique, sinusite, conjonctivite, allergies alimentaires, psoriasis, urticaire, prurit, eczéma, polyarthrite rhumatoïde, maladies entériques inflammatoires, sclérose en plaques, athérosclérose.
Defais Francoise
Demaude Thierry
Guillaumet Gerald
Knerr Laurent
Kogej Thierry
Robic
Ucb S.a.
Ucb Pharma S.a.
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