2,6 quinolinyl derivatives, processes for preparing them and...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/12 (2006.01) A61K 31/4709 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2610800

The present invention concerns 2.6-quinolinyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceu ticals. For example, the compounds according to the invention are useful for the treatment of asthma, allergic rhinitis, sinusitis, conjunctivitis, food allergy, inflammatory skin disorders including dermatitis, psoriasis, urticaria, pruritus and eczema, rheumatoi arthritis, inflammatory bowel diseases including Crohn's disease and ulcerative colitis, multiple sclerosis and other autoimmune disorders, and atherosclerosis.

Dérivés de 2,6-quinolinyle, procédés d'élaboration, compositions pharmaceutiques les contenant et leur utilisation comme produits pharmaceutiques. Par exemple, ces composés sont utiles pour le traitement des maladies suivantes : asthme, rhinite allergique, conjonctivite, allergie alimentaire, troubles dermatologiques inflammatoires y compris la dermatite, le psoriasis, l'urticaire, le prurit et l'eczéma, la polyarthrite rhumatoïde, les maladies intestinales inflammatoires y compris la maladie de Crohn et la colite ulcéreuse, la sclérose en plaque et d'autres maladies auto-immunes, ainsi que l'athérosclérose.

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