2,6-substituted-4-monosubstituted amino-pyrimidine as...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/46 (2006.01) C07D 239/48 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2583742

The present invention is directed a compound of Formula (I) as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, discorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (I).

La présente invention a trait à un composé de formule (I) dans laquelle: Cy1, Cy2, L1, L2 et R1 sont tels que définis dans la description, à une composition pharmaceutique comprenant une quantité pharmaceutiquement efficace d'un ou de plusieurs composés de formule (I) en mélange avec un support pharmaceutiquement acceptable, et à un procédé de traitement d'un patient souffrant d'un trouble médié par la PGD2 comprenant, mais de manière non limitée, une maladie allergique (telle que la rhinite allergique, la conjonctivite allergique, la dermatite atopique, l'asthme et l'allergie alimentaire), la mastocytose systémique, des troubles accompagnés d'activation des mastocytes, le choc anaphylactique, la bronchoconstriction, la bronchite, l'urticaire, l'eczéma, les maladies accompagnées de démangeaison (telles que la dermatite atopique et l'urticaire), des maladies (telles que la cataracte, le décollement de la rétine, l'inflammation, l'infection et les troubles du sommeil) qui sont générées de manière secondaire conséquentes à un comportement accompagné de démangeaison (telles que griffures et battade), l'inflammation, les maladies obstructives respiratoires, la lésion ischémique au retour de la perfusion, l'accident vasculaire cérébral, la polyarthrite rhumatoïde chronique, la pleurésie, la colite ulcéreuse et analogues par l'administration au dit patient d'une quantité pharmaceutiquement efficace d'un composé de formule (I).

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