2,7-diazabicyclo[3.3.0]octanes and a process for their...

Details 2,7-diazabicyclo[3.3.0]octanes and a process for their... 2,7-diazabicyclo[3.3.0]octanes and a process for their...

C - Chemistry, Metallurgy

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D

260/272, 260/285

C07D 471/14 (2006.01) A61K 31/395 (2006.01) C07C 271/18 (2006.01) C07D 487/04 (2006.01) C07D 487/14 (2006.01) C07D 513/04 (2006.01) C07D 513/14 (2006.01)

Patent

CA 2014478

Abstract 2,7-Diazabicyclo[3.3.0]octanes, suitable for 7-position substituents or antibacterially active quinolone carboxylic acids, of the formula Image (I) in which R1, R3, R4, R5, R7 and R8 may be identical or different and in each case denote H, C1-C5-alkyl (optionally sub- stituted by halogen, hydroxyl or C1-C3-alkoxy), C1- C3-alkoxycarbonyl or C6-C12-aryl, R4 additionally denotes halogen, R2 and R6 may be identical or different, denote H, C1-C6- alkyl, benzyl, C6-C12-aryl, C1-C3-alkanoyl, benzoyl or C1-C5-alkoxycarbonyl , or R2 and R3 together denote a bridge of the structure (CH2)n, n = 2-4, CH2-CHOH-CH2, CH2-S-CH2 or C(CH3)2-S-CH2, excluding 2,7-diazabicyclo[3.3.0]octane. Also their preparation by the reaction Image (II) (III) Intermediates II are also new. Le A 26 686

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