C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/277.3, 260/2
C07D 401/12 (2006.01) C07D 211/08 (2006.01) C07D 215/16 (2006.01) C07D 215/44 (2006.01)
Patent
CA 1067080
ABSTRACT The specification discloses a process for the pre- paration of a NEW compound, which exhibits anti-inflammatory activity, having the general formula Image or an acid addition salt thereof, wherein X is a halogen atom or a trifluoromethyl group, % is hydrogen, halogen, trifluoro- methyl, lower alkyl, lower alkoxy, hydroxyl, nitro, amino or mono- or di-alkyl substituted amino, R1 represents hydrogen or lower alkyl, and R2 represents [mono(lower alkyl)amino] (lower alkyl), [di(lower alkyl)amino](lower alkyl), piperidyl, 1-[ar(lower)alkyl]-piperidyl or 1-(lower alkyl)piperidyl or -?R2R2 represents [mono(lower alkyl)amino]piperidino or [di(lower alkyl)amino]piperidino, whereby either (a) a compound of the formula ??R1R2, or a corresponding compound with an activated amino group, is acylated with a compound having the formula Image or a corresponding compound with a protecting group, or a re- active derivative of this compound or its corresponding compound with m protecting group, or (b) a compound having the formula Image or a corresponding compound with a protecting group, is reacted with a compound having the formula Image wherein Y denotes a group or atom replaceable by nucleophilic attack by the compound having the formula Image .
244164
Archibald John L.
Boyle John T.a.
Saunders John C.
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