2,7-substituted octahydro-1h-pyrido[1,2-a]pyrazine derivatives

Details 2,7-substituted octahydro-1h-pyrido[1,2-a]pyrazine derivatives 2,7-substituted octahydro-1h-pyrido[1,2-a]pyrazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2200959

Substituted pyrido[1,2-a]pyrazines of general formula (I) wherein Ar and Ar1 represent various carbocyclic and heterocyclic aromatic rings; A represents O, S, SO, SO2, C=O, CHOH, or -(CR3R4) and n is 0-2 as well as precursors thereto are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment of disorders of the dopamine system.

On décrit des pyrido[1,2-a] pyrazines substituées pyrido[1,2-a], de formule générale (I), où Ar et Ar?1¿ représentent différents cycles aromatiques carbocycliques et hétérocycliques, A représente O, S, SO, SO¿2?, C=O, CHOH, ou -(CR?3¿R?4¿), et n vaut de 0 à 2. Elles constituent, de même que des précurseurs, des ligands de sous-types de récepteurs de la dopamine présents dans le corps et se révèlent donc utiles pour traiter des troubles du système dopamine.

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