2,8-disubstituted naphthyridine derivatives

Details 2,8-disubstituted naphthyridine derivatives 2,8-disubstituted naphthyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2575571

Disclosed are compounds of formula (A) and pharmaceutically acceptable salts thereof, wherein R1, R2, R2' , R3, R21, A1, A2, X, and Z are defined herein. Compounds of formula (A) are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

L'invention concerne des composés de formule A et des sels acceptables sur le plan pharmaceutique de ceux-ci, dans laquelle R1, R2, R21, R3, R21, A1, A2, X, et Z ont la signification indiquée dans la description. Lesdits composés de formule A sont utiles dans le traitement de maladies et/ou d'états associés à la différenciation cellulaire, de type cancer, inflammation, arthrite, angiogenèse, ou analogues. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés ainsi que des méthodes de traitement des états précédemment mentionnés au moyen desdits composés.

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