C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/02 (2006.01) A61K 31/00 (2006.01) C07C 237/06 (2006.01) C07C 237/22 (2006.01) C07C 271/20 (2006.01) C07D 209/08 (2006.01) C07D 209/42 (2006.01) C07D 211/34 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 213/89 (2006.01) C07D 215/08 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01) C07D 215/18 (2006.01) C07D 215/20 (2006.01) C07D 215/36 (2006.01) C07D 215/38 (2006.01) C07D 215/54 (2006.01) C07D 215/56 (2006.01) C07D 217/02 (2006.01) C07D 221/12 (2006.01) C07D 223/16 (2006.01) C07D 23
Patent
CA 2158227
Compounds of the formula I Image (1), in which R1 is arylamino, N-aryl-N-(lower alkoxy-lower alkyl)-amino, N-aryl-N-aryl-lower alkyl-amino or heterocyclyl bonded via a ring carbon atom, X is a carbonyl or methylene group, R2 and R3 independently of one another are hydrogen or lower alkyl or, together with the carbon atom with which they are bonded, are a cycloalkylidene radical, R4 is hydrogen, lower alkyl, lower alkanoyl or lower alkoxycarbonyl, R5 is hydroxyl, lower alkanoyloxy or lower alkoxy- carbonyloxy, R6 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkyl- lower alkyl, aryl-lower alkyl or heteroaryl-lower alkyl having 5 to 7 ring atoms in the heteroaryl ring and R7 is hydrogen or lower alkyl, or R6 and R7, together with the carbon atom with which they are bonded, are a cycloalkylidene radical and R8 denotes an aliphatic, cycloaliphatic-aliphatic or heteroarylaliphatic radical, and their salts can be used as active ingredients for medicaments for treatment of high blood pressure.
Cohen Nissim Claude
Grutter Markus
Mah Robert
Maibaum Jurgen Klaus
Rasetti Vittorio
Fetherstonhaugh & Co.
Novartis Ag
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