2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid...

C - Chemistry – Metallurgy – 07 – D

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C07D 215/02 (2006.01) A61K 31/00 (2006.01) C07C 237/06 (2006.01) C07C 237/22 (2006.01) C07C 271/20 (2006.01) C07D 209/08 (2006.01) C07D 209/42 (2006.01) C07D 211/34 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 213/89 (2006.01) C07D 215/08 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01) C07D 215/18 (2006.01) C07D 215/20 (2006.01) C07D 215/36 (2006.01) C07D 215/38 (2006.01) C07D 215/54 (2006.01) C07D 215/56 (2006.01) C07D 217/02 (2006.01) C07D 221/12 (2006.01) C07D 223/16 (2006.01) C07D 23

Patent

CA 2158227

Compounds of the formula I Image (1), in which R1 is arylamino, N-aryl-N-(lower alkoxy-lower alkyl)-amino, N-aryl-N-aryl-lower alkyl-amino or heterocyclyl bonded via a ring carbon atom, X is a carbonyl or methylene group, R2 and R3 independently of one another are hydrogen or lower alkyl or, together with the carbon atom with which they are bonded, are a cycloalkylidene radical, R4 is hydrogen, lower alkyl, lower alkanoyl or lower alkoxycarbonyl, R5 is hydroxyl, lower alkanoyloxy or lower alkoxy- carbonyloxy, R6 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkyl- lower alkyl, aryl-lower alkyl or heteroaryl-lower alkyl having 5 to 7 ring atoms in the heteroaryl ring and R7 is hydrogen or lower alkyl, or R6 and R7, together with the carbon atom with which they are bonded, are a cycloalkylidene radical and R8 denotes an aliphatic, cycloaliphatic-aliphatic or heteroarylaliphatic radical, and their salts can be used as active ingredients for medicaments for treatment of high blood pressure.

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