C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/239
C07D 243/16 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)
Patent
CA 1173440
ABSTRACT OF THE DISCLOSURE Novel 2-acyl amino methyl-5-phenyl-1H-2,3-dihydro-1,4- benzo diazepine compounds of the following Formula I Image which have valuable pharmacological properties are provided. In said formula I the acyl group -CO-R3 represents a benzoyl group or a phenyl alkanoyl group which may be unsubstituted or mono- or di-sub- stituted in the phenyl ring. The substituent R1 in said compounds indicates lower alkyl, lower alkenyl, or cyclopropyl methyl, and the substituent R2 indicates hydrogen, lower alkyl, or lower alkenyl, while the substituent R6 indicates hydrogen, halogen, lower alkyl, lower alkoxy, hytroxyl, lower alkylthio, nitro, trifluoro methyl, cyano, amino, mono- or di-lower alkyl amino, lower mono-alkanoyl amino, lower N-alkyl-N-alkanoyl amino, or lower alkanoyloxy, and the substituent R7 indicates hydrogen, halogen, lower alkyl, lower alkoxy, hydroxyl, or lower alkanoyloxy, whereby R6 and R7, when attached to adjacent carbon atoms, may form together the methylene dioxy or the ethylene dixy group. The substituents R8 and R9 designate the same substituents as indicated for the substituents R6 and R7. The compounds of Formula I have a surprising analgesic activity.
392654
Liepmann Hans
Milkowski Wolfgang
Romer Dietmar
Zeugner Horst
Solvay Pharmaceuticals Gmbh
Swabey Ogilvy Renault
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